Беременность и Роды. Том - 7-ой ( зимний)

[Багира]

Что то я не понимаю по Сенсиблексу
На официальном сайте его не нашла.
http://www.veyx.de/englisch/navigati...tion_start.htm
Тут говорят, что это вариант но шпы.
Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]
[edit]Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.
Pharmacology
Denaverine hydrochloride has a pronounced spasmolytic effect with good tolerance and low toxicity. The spasmolytic effect is mainly musculotropic and is stronger than that of papaverine. The level of analgesic efficacy is between 40 and 90 % of morphine strength, depending on the trial design.
Application of denaverine is followed by a pronounced tone reduction and labour contraction regulating effect in rat uteri in situ spastically contracted with Oxytocin. The influence on the cardiovascular system is minimal. Respiration frequency and volume are increased in anaesthetized rabbits. The antihistamine effect of denaverine hydrochlo- ride was minimal, the antipyretic effect good. About one-third of the dose adminis- tered was recovered unchanged in urine. Maximum elimination was reached between the 4th and 8th hour after administration. No more unaltered substance was recovered in the urine on the 2nd day following application.
Local tolerance is very good. Acute LD50 is as follows: in mice 137.5 mg/kg body weight, in rats 112 mg/kg body weight, following intravenous application. Following long-term treatment of mice, rats and dogs with denaverine hydrochloride in tests of chronic toxicity, no significant differences in the test parameters (behaviour, feed intake, growth, blood picture, organ histology) were determined between the control and denaverine groups.

Для сравнения:

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.

A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic. It has also been studied in accelerating labor by speeding up cervical dilation, but the results have been conflicting. Drotaverine has been shown to be effective in paracervical block in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid. IBS patients presenting with predominant diarrhea are more likely to benefit from Buscopan. Drotaverin has also been tested in combination with rimantadine for antiviral activity against A and B type influenza. Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.
Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis).
Девочки кто уже применял Сенсиблекс до него Вы применяли но шпу в уколах? Для сравнения.

[ДаЯдЭ]

Багира, по сенисеблекс, вы сами ответили на свой вопрос - нош-па - это дротоверин, а сенсиблекс - денаверина гидрохлорид. Препараты разные... Ну для сравнения можно предположить, что начали мы с пеницилина... а потом уже все остальное.
Кто-то называет сенисеблекс продвинутой но-шпой, так что плохого, если помогает?

[yorki-passion.ru]

а у нас шевелюшечки!!!!
еле заметные, но точно есть

[Vishenka]

yorki-passion.ru, с шевелюшками вас! Это так приятно!

[yorki-passion.ru]

Deva,
Lisi Koker, Vishenka,
piternewf, спасибище большущее!
это просто кайф....
правда только с одной стороны живота пока

[piternewf]

yorki-passion.ru,
Поздравляем с шевелюшками!

[Vishenka]

Я сегодня разговаривала со старой знакомой. У нее рожала чихуашка. Она готовилась к родам. Наступила ночь. не выдержала, заснула. Проснулась в ужасе, что все проспала И что она увидела ... Мамочка лежит с тремя детками. Детки чистенькие, сосут вовсю. Неужели такое бывает? Какое счастье, когда собака, тем более из мелких так рожает. Девочки, желаю всем вам таких вот легких родов! И нам тоже!

[Lisi Koker]

Vishenka,А температура изменилась?

[Vishenka]

Сообщение от Lisi Koker

Vishenka,А температура изменилась?

Люда в 13.00 была 37,5 сейчас 37, 8. Вообщем повышается.

[Deva]

yorki-passion.ru,
Поздравляю с шевелюшками!!!